Interactive, Visual 3D Modeling - In this case study, you will learn various interactive ligand optimization strategies. We will start with the computation of approximate protein-ligand binding affinities that can be visualized; the graphical feedback will help us with our subsequent optimization decisions - with or without a protein. You will learn how to dock using incremental build-up strategies. A fragment-based approach to explore pockets will be introduced; visual feedback with underlying torsion angle statistics will guide us. Moreover, we will conduct rescaffolding in 3D, and conduct mix & match from multiple ligands. SeeSAR is throughout.