Funnel Metadynamics Automated Protocol (FMAP): three steps to discover the drug pharmacodynamics. Funnel-Metadynamics (FM) is a binding free-energy technique able to identify the ligand binding mode and provide an accurate estimation of the absolute protein-ligand binding free energy. In this hands-on tutorial, we show how to setup a system for FM calculations and how to analyse the results in the prototypical case benzamidine/trypsin. After the tutorial session, the participants can propose systems of their interest to familiarise with the technique and favour the discussion with the whole class.