Orion is OpenEye’s reimagining of computational drug discovery and design by the cloud. It includes all of OpenEye’s software, extensive tools for data visualization and communication, useful data sources and task-oriented workflows – all in a robust, scalable, cloud environment. Orion is an open platform that allows for straightforward integration of third-party code (customer, academic, vendor). It also includes Floe, a new graphical workflow engine, that makes it simple to construct scripts to take advantage of all that Orion has to offer. In the workshop we will utilize Orion to combine ligand- and structure-based methods, modify research protocols and analyze the results along the way.